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Acute Lymphoblastic Leukemia (All) and Interferon Beta-1 Gene: Mutational Analysis of Interferon Beta 1 (Ifn1) Gene in Blood Cancer Patients of Acute Lymphoblastic Leukemia (All)
Abdul Rauf Shakoori
Acute Lymphoblastic Leukemia (All) and Interferon Beta-1 Gene: Mutational Analysis of Interferon Beta 1 (Ifn1) Gene in Blood Cancer Patients of Acute Lymphoblastic Leukemia (All)
Abdul Rauf Shakoori
Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of early non-granular white blood cells, or lymphoblasts. ALL occurs predominantly in children, peaking at 4 years of age. Interferons (IFNs) are the biological agents involved in the antiviral responses and the inhibition of tumor growth. In oncology, the IFNs are an important treatment options for a number of solid tumors and hematological malignancies. The IFN-?1gene consists of 840 bp and it lacks intron sequences. Seventy patients suffering from Childhood Acute Lymphoblastic Leukemia were studied and analyzed for mutation analysis of IFN-?1. So, 58.3% of the patients suffering from ALL were observed and compared with 41.7% normal DNA samples as control. PCR was performed and amplified gene products were detected on agarose gel and PAGE. Finally, SSCP was performed and mobility shift was observed in 7 out of 70 ALL samples. We observed that ALL disease typically develops in children ages 1-10 years old and is more prevalent in males than females. Mutation in the IFN-?1 gene was significantly related to 1-5 years in case of association of mutation with age.
Médias | Livres Paperback Book (Livre avec couverture souple et dos collé) |
Validé | 31 août 2012 |
ISBN13 | 9783659230417 |
Éditeurs | LAP LAMBERT Academic Publishing |
Pages | 172 |
Dimensions | 150 × 10 × 226 mm · 258 g |
Langue et grammaire | English |
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